Research

Research

List of Past Experiments

Sources

Invasive procedures

Albertson BD, Hobson WC, et al. 1984 Dissociation of cortisol and adrenal androgen secretion in the hypophysectomized, adrenocorticotropin-replaced chimpanzee. J Clin Endocrinol Metab. 1984 Jul;59(1):13-8.

Delgado JM. 1969 Implantation of multilead electrode assemblies and radio stimulation of the brain in chimpanzees. Tech Doc Rep ARL TDR. Mar; 1-19.

Gilbertsen RB, Metzgar RS. 1978 Depression of T lymphocyte function in chimpanzees receiving thymectomy and irradiation. Transplantation. Mar;25(3):103-9.

Gilbertsen RB, Metzgar RS, Seigler HF. 1974 Immunologic studies on T and B lymphocytes in chimpanzees: effects of thymectomy and irradiation. Transplant Proc. Jun;6(2):183-8.

Leonard A, Decat G, Leonard ED, Mortelmans J. 1977 The chromosomal radiosensitivity of lymphocytes from the chimpanzee (Pan troglodytes). Mutat Res. Oct;45(1):69-76.

Paravatou-Petsota M, Muleris M, Prieur M, Dutrillaux B. 1985 Diagrammatic representation for chromosomal mutagenesis studies. III. Radiation-induced rearrangements in Pan troglodytes (chimpanzee). Mutat Res. Mar;149(1):57-66.

Rosvold HE, Szwarcbart MK, Mirsky AF, Mishkin M. The effect of frontal-lobe damage on delayed response performance in chimpanzees. J Comp Physiol Psychol. 1961 Aug;54:368-74.

Traeger, J. Transplantations of kidneys from chimpanzees to man. 1969 Primates Med.;3(0):52-4.

Poisoning

NIH Grant 2N01CP081027-00178: Maintenance of chimpanzees for cancer research, 1979.

Schellekens H, de Reus A, vd Meide, PH. 1984 The chimpanzee as a model to test the side effects of human interferons. J Med Primatol. 1984;13(5):235-45.

Tabor E, Gerety RJ, et al. 1978 Effect of ethanol during hepatitis B virus infection in chimpanzees. J Med Virol. 2(4):295-303.

Physical trauma

See documentation for Air & Space.

Coburn KR, Craig PH, Beckman EL. Effects of Positive G on Chimpanzees Immersed in Water. Aerosp Med. 1965 Mar;36:233-45.

Douglass JM, Nahum AM, Roberts SB. 1972 Impedance changes in deep brain structures following experimental head impact in primates. J Trauma. Apr;12(4):315-26.

Engin AE, Akkas N. 1978 Application of a fluid-filled spherical sandwich shell as a biodynamic head injury model for primates. Aviat Space Environ Med. Jan;49(1 Pt. 2):120-4.

Hawrylewicz EJ, Blair WH. Biochemical measure of impact stress in chimpanzees. Aerosp Med. 1965 Apr;36:369-71.

Koestler AG, Reynolds HH. 1968 Rapid decompression of chimpanzees to near vacuum. J Appl Physiol. Aug 25(2):153-8.

Ommaya AK, Corrao P, Letcher FS. 1973 Head injury in the chimpanzee. 1. Biodynamics of traumatic unconsciousness. J Neurosurg. Aug;39(2):152-66.

Ommaya AK, Hirsch AE. 1971. Tolerances for cerebral concussion from head impact and whiplash in primates. J Biomech. Jan;4(1):13-21.

Mental trauma

The Ape and The Child: A Comparative Study of the Environmental Influence Upon Early Behavior. Davenport RK Jr, Menzel EW Jr, Rogers CM. Effects of severe isolation on “normal” juvenile chimpanzees. Health, weight gain, and stereotyped behaviors. Arch Gen Psychiatry. 1966 Feb;14(2):134-8.

Infectious and fatal diseases

Arko RJ, Duncan WP, Brown WJ, Peacock WL, Tomizawa T. Immunity in infection with Neisseria gonorrhoeae: duration and serological response in the chimpanzee. J Infect Dis. 1976 Apr;133(4):441-7.

Atchley FO, Kimbrough RD. Experimental study of infectious hepatitis in chimpanzees. Lab Invest. 1966 Oct;15(10):1520-7.

Cathala F, Hauw JJ, Escourolle R, Chany C, Castaigne P. 1973 Transmission of experimental subacute spongiform encephalopathy (Creutzfeldzt-Jakob disease) from chimpanzee to chimpanzee. Biomedicine. Jul;18(4):328-35

Court L, Cathala F, Gajdusek DC, Rohmer F. Modification of behavior, vigilance and spontaneous cerebral electrical activity in a case of experimental Creutzfeldt-Jakob disease in the chimpanzee Rev Electroencephalogr Neurophysiol Clin. 1975 Oct-Dec;5(4):335-43.

Gaines S, Tully JG, Tigertt WD 1968. Studies on infection and immunity in experimental typhoid fever. 8. Intravenous and intra-lymph node challenge of chimpanzees with Salmonella typhi. J Infect Dis. Oct;118 (4):393-401.

Gibbs CJ Jr, Gajdusek DC, Asher DM, Alpers MP, Beck E, Daniel PM, Matthews WB. 1968 Creutzfeldt-Jakob disease (spongiform encephalopathy): transmission to the chimpanzee. Science. Jul 26;161(839):388-9.

Godfrey DG, Killick-Kendrick R. Cyclically transmitted infections of Trypanosoma brucei, T. rhodesiense and T. gambiense in chimpanzees. Trans R Soc Trop Med Hyg. 1967;61(6):781-91.

Kaufmann CA, Weinberger DR, Stevens JR, Asher DM, Kleinman JE, Sulima MP, Gibbs CJ Jr, Gajdusek DC. 1988 Intracerebral inoculation of experimental animals with brain tissue from patients with schizophrenia. Failure to observe consistent or specific behavioral and neuropathological effects. Neuropsychiatry Branch, St Elizabeths Hospital, Washington, DC 20032. Arch Gen Psychiatry. Jul;45(7):648-52.

Lief FS, Rorke LB, Kalter SS, Hoffman SF, Roosa RA, Moore GT, Cummins LB, McCullough B, Rodriguez AR, Eichberg J, Koprowski H. Infection and disease induced in chimpanzees with 6/94, a parainfluenza type 1 virus isolated from human multiple sclerosis brain. J Neuropathol Exp Neurol. 1976 Nov-Dec;35(6):644-64.

Rogers NG, Basnight M, Gibbs CJ, Gajdusek DC. Latent viruses in chimpanzees with experimental kuru. Nature. 1967 Nov 4;216(114):446-9.

Rorke LB, Iwasaki Y, Koprowski H, Wroblewska Z, Gilden DH, Warren KG, Lief FS, Hoffman S, Cummins LB, Rodriguez AR, Kalter SS. 1979. Acute demyelinating disease in a chimpanzee three years after inoculation of brain cells from a patient with MS. Ann Neurol. Jan;5(1):89-94.

Sadun EH, Hickman RL, Wellde BT, Moon AP, Udeozo IO. Active and passive immunization of chimpanzees infected with West African and Southeast Asian strains of Plasmodium falciparum. [malaria] Mil Med. 1966 Sep;131(9):Suppl:1250-62.

Simkova A, Danes L. Virological and clinical observations on chimpanzees exposed to Tahyna virus aerosol. Acta Virol. 1968 Sep;12(5):474.

Tully Jg, Gaines S, Tigertt Wd. Studies on Infection and Immunity in Experimental Typhoid Fever. V. Respiratory Challenge of Chimpanzees with Salmonella Typhosa. J Infect Dis. 1963 Sep-Oct;113:131-8.

Chimpanzee bodies as bioreactors

Americans for Medical Advancement, “Hepatitis C and Chimpanzees.” At http://www. curedisease.com/articleHCV.html

Greek R, Shanks N, Greek J, “A Scientific Case for the Elimination of Chimpanzees in Research,” Americans for Medical Advancement, 2005

Reproductive/sex

Barton BR, Hertig AT. 1972. Ultrastructure of annulate lamellae in primary oocytes of chimpanzees (Pan troglodytes). Biology of Reproduction Feb;6(1):98-108.

Cummins LB, Kalter SS. 1980 Production and standardization of the chimpanzee for research. Dev Biol Stand. 45:67-72.

Coulston F. 1981 Perspectives for the use of indazolecarboxylic acids as male antifertility agents. Chemotherapy. Suppl 2:98-101.

Fussell EN, Franklin LE, Frantz RC. 1973. Collection of chimpanzee semen with an artificial vagina. Lab Anim Sci. Apr;23(2):252-5.

Gould KG, Martin DE. 1974. Energy dispersive x-ray analysis: application to assessment of spermatoan viability in primate semen. ICRS J Int Res Commun. Jul;2(7):1445.

Graham CE, Gould KG, et al 1979. Regulation of gonadotropin release by luteinizing hormone-releasing hormone and estrogen in chimpanzees. Endocrinology. Jul;105(1):269-75.

Grilly DM, Ferraro DP, Braude MC. 1974. Observations on the reproductive activity of chimpanzees following long-term exposure to marihuana. Pharmacology. 11(5):304-7.

Martin, D.E. 1980 “Artificial breeding of chimpanzees” NIH Grant 2R24RR000992-03A1, Emory University.

Olson GE, Gould KG. 1981. Characterization of sperm surface and seminal plasma glycoproteins of the chimpanzee. J Reprod Fertil. May;62(1):185-91.

Ozasa H, Gould KG. 1982. Demonstration and characterization of estrogen receptor in chimpanzee sex skin: correlation between nuclear receptor levels and degree of swelling. Endocrinology. Jul;111(1):125-31.

Srivastava PN, Farooqui AA, Gould KG. 1981 Studies on hydrolytic enzymes of chimpanzee semen. Biol Reprod. 1981 Sep;25(2):363-9.

Drug dosing and addiction

Byrd LD. 1975. Contrasting effects of morphine on schedule-controlled behavior in the chimpanzee and baboon. J Pharmacol Exp Ther. 1975 Jun;193(3):861-9

Byrd LD. 1980. Magnitude and duration of the effects of cocaine on conditioned and adjunctive behaviors in the chimpanzee. J Exp Anal Behav. Jan;33(1):131-40.

Ferraro DP, Billinos DK. 1972. Comparison of behavioral effects of synthetic (-) 9 -trans-tetrahydrocannabinol and marihuana extract distillate in chimpanzees. Psychopharmacologia. 25(2):169-74.

Ferraro DP, Grilly DM. 1973. Lack of tolerance to 9 -tetrahydrocannabinol in chimpanzees. Science. Feb 2;179(72):490-2.

Ferraro DP, Grilly DM. 1974. Effects of chronic exposure to delta9-tetrahydrocannabinol on delayed matching-to-sample in chimpanzees. Psychopharmacologia. Jun 21;37(4):127-38.

Grilly DM, Ferraro DP, Marriott RG. 1973. Long-term interactions of marijuana and behaviour in chimpanzees. Nature. 1973 Mar 9;242(5393):119-20.

Pieper WA. Great apes and rhesus monkeys as subjects for psychopharmacological studies of stimulants and depressants. Fed Proc. 1976 Sep;35(11):2254-7.

Pieper WA, Skeen MJ. 1973. Changes in blood methanol concentrations in chimpanzees during periods of chronic ethanol ingestion. Biochem Pharmacol. Jan 15;22(2):163-73.

Pieper WA, Skeen MJ. 1973. Changes in rate of ethanol elimination associated with chronic administration of ethanol to chimpanzees and rhesus monkeys. Drug Metab Dispos. 1973 Jul-Aug;1(4):634-41.

Pieper WA, Skeen MJ, McClure HM, Bourne PG. 1972. The chimpanzee as an animal model for investigating alcoholism. Science. Apr 7;176(30):71-3.

Unwilling organ donors

PBS Frontline, Organ Farm, March 27, 2001, “A History of Xenotransplantation Experiments

Tulane University Health Sciences Center, Rudolph Matas Medical Library, Tulane University Contributions to Medical Science and Education

Stark, Tony. Knife to the Heart: The Story of Transplant Surgery. Macmillan 1996. Chapter 7: pp 156-7.

 

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