The information for this summary was obtained from the NIH CRISP database (Computer Retrieval of Information on Scientific Projects). CRISP offers a database of all projects federally funded since 1972. Most projects have accompanying abstracts. Information presented below in italics is quoted directly from the CRISP abstract.
Funding amounts were obtained from http://grants.nih.gov/grants/award/
NOTE: Funding and dates of studies are available only for NIH studies conducted off-site. This information is not available for studies conducted at NIH laboratories (referred to as intramural research).
| Researcher: | Anna Aldovini |
| Grant No. | 5R21AI055291-02 |
| Project: | Lentiviral modulation of gene expression in target cells |
| Institution: | Children’s Hospital, Boston MA * |
| Project runs: | April 1, 2003 - March 31, 2005 |
| Funding: | $243,000 |
| Researcher: | Harvey J. Alter |
| Grant No. | 1Z01CL002082-09 |
| Project: | Viral Hepatitis and AIDS in Animal Model |
| Institution: | NIH/Intramural |
| Project runs: | Unavailable/ project in 9th year |
| Funding: | Unavailable |
For more information on this project, see K. Murthy below.
| Researcher: | Hildegund Ertl |
| Grant No. | 5P01AI052271-03 |
| Project: | HIV-1 Vaccine Based on Chimp Serotypes of Adenovirus |
| Institution: | Wistar Institute, Philadelphia, PA * |
| Project runs: | September 15, 2002 - June 30, 2007 |
| Funding: | $1,903,655 |
In this experiment, chimpanzees are injected with varying strains of HIV to produce antibodies for the virus. They are then used as test subjects to evaluate treatments and vaccines for HIV.
| Researcher: | Krishna H. Murthy |
| Grant No. | 2P51RR013986-060186 |
| Project: | HIV-1 Adenovirus-Based Vaccine Study in Chimpanzees |
| Institution: | Southwest Foundation for Biomedical Research, San Antonio |
| Project runs: | May 1, 2004 - April 30, 2005 |
| Funding: | $6,004,828 ** for 2P51RR013986-06 |
No CRISP abstract is available for this project. The following excerpt was taken from a paper published by Krishna Murthy, Harvey Alter and others:
… chimpanzee (X034) was inoculated with 38 median tissue culture infective doses of HIV-1 IIIB; serum and peripheral blood mononuclear cells were obtained one to two times per week for 12 weeks and then biweekly for 12 weeks. … RESULTS: No HIV markers were noted until 5 weeks after inoculation, at which time virus was isolated and HIV RNA and DNA were detected in plasma and cells, respectively. … Plasma and cells obtained from Chimpanzee X034 3 or 4 weeks after exposure were then sequentially inoculated into a second chimpanzee (X176); no HIV infection was observed in this animal during serial follow-up for 24 weeks after each inoculation. In contrast, when the fifth-week HIV-1 RNA- and DNA-positive sample was inoculated, Chimpanzee X176 was unequivocally infected with HIV-1. (1)
Sources
(1) Murthy KK, Henrard DR, Eichberg JW, Cobb KE, Busch MP, Allain JP, Alter HJ. Redefining the HIV-infectious window period in the chimpanzee model: evidence to suggest that viral nucleic acid testing can prevent blood-borne transmission. Transfusion. 1999 Jul;39(7):688-93
** This project is part of a larger award. The amount indicated is for all components of the parent grant. The amount specific to this component is not available due to limitations in data made available by NIH.